In vivo nucleus basalis of Meynert degeneration in mild cognitive impairment with Lewy bodies
نویسندگان
چکیده
منابع مشابه
Volume Loss of the Nucleus Basalis of Meynert is Associated with Atrophy of Innervated Regions in Mild Cognitive Impairment.
Extensive research suggests that basal forebrain (BF) cholinergic neurons are selectively vulnerable to Alzheimer's disease (AD). However, it remains unknown whether volume loss of BF cholinergic compartments parallels structural changes of their innervated regions in prodromal AD. To this aim, we have correlated volume of each BF compartment with cortical thickness and hippocampus/amygdala vol...
متن کاملVALIDATION OF BRIEF COGNITIVE TESTS in mild cognitive impairment, Alzheimer’s disease and dementia with Lewy bodies
....................................................................................................... 8 Sammanfattning .......................................................................................... 9 Abbreviations ............................................................................................ 11 1 Introduction to neurodegenerative diseases ...........................
متن کاملHippocampal volumes predict risk of dementia with Lewy bodies in mild cognitive impairment
OBJECTIVE To predict the risk of probable dementia with Lewy bodies (DLB) competing with Alzheimer disease (AD) dementia by hippocampal volume (HV) in patients with mild cognitive impairment (MCI) with impairments in amnestic or nonamnestic cognitive domains. METHODS Patients with MCI (n = 160) from the Mayo Clinic Alzheimer's Disease Research Center, who participated in an MRI study at basel...
متن کاملQuantitative electroencephalogram utility in predicting conversion of mild cognitive impairment to dementia with Lewy bodies☆
Mild cognitive impairment (MCI) as a precursor of dementia with Lewy bodies (DLB) is the focus of recent research, trying to explore the early mechanisms and possible biomarkers of DLB. Quantitative electroencephalogram (QEEG) methods are able to differentiate early DLB from Alzheimer's disease (AD). The aim of the present study was to assess whether QEEG abnormalities, characterized by dominan...
متن کاملIncreased metabolic activity in nucleus basalis of Meynert neurons in elderly individuals with mild cognitive impairment as indicated by the size of the Golgi apparatus.
In this study, we examined the metabolic activity of nucleus basalis of Meynert (NBM) neurons in individuals clinically diagnosed with no cognitive impairment (NCI, n = 8), mild cognitive impairment (MCI, n = 9), and subjects with moderate Alzheimer disease (AD, n = 7). We used Golgi apparatus (GA) size as a measure of neuronal metabolic activity. Subjects with MCI showed increased NBM metaboli...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: NeuroImage: Clinical
سال: 2021
ISSN: 2213-1582
DOI: 10.1016/j.nicl.2021.102604